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1

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

Chiho Hirata-Fukae, Hui-Fang Li, Hyang-Sook Hoe, Audrey J. Gray, S. Sakura Minami, Katsuyoshi Hamada, Takako Niikura, Fang Hua, Hiroe Tsukagoshi-Nagai, Yuko Horikoshi-Sakuraba, Mohamed Mughal, G. Will

Journal:

Year:

2008

Language:

english

File:

PDF, 2.03 MB

english, 2008

2

Levels of soluble and insoluble tau reflect overall status of tau phosphorylation in vivo

Chiho Hirata-Fukae, Hui-Fang Li, Li Ma, Hyang-Sook Hoe, G. William Rebeck, Paul S. Aisen, Yasuji Matsuoka

Journal:

Neuroscience Letters

Year:

2009

Language:

english

File:

PDF, 959 KB

english, 2009

3

The Correlation between Postmenopausal Osteoporosis and Inflammatory Periodontitis Regarding Bone Loss in Experimental Models

Kobayashi, Megumi, Matsumoto, Chiho, Hirata, Michiko, Tominari, Tsukasa, Inada, Masaki, Miyaura, Chisato

Journal:

Experimental Animals

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

4

Influence of contamination on banded iron formations in the Isua supracrustal belt, West Greenland: Reevaluation of the Eoarchean seawater compositions

Aoki, Shogo, Kabashima, Chiho, Kato, Yasuhiro, Hirata, Takafumi, Komiya, Tsuyoshi

Journal:

Geoscience Frontiers

Year:

2017

Language:

english

File:

PDF, 4.79 MB

english, 2017

5

Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice

Tominari, Tsukasa, Ichimaru, Ryota, Taniguchi, Keita, Yumoto, Akane, Shirakawa, Masaki, Matsumoto, Chiho, Watanabe, Kenta, Hirata, Michiko, Itoh, Yoshifumi, Shiba, Dai, Miyaura, Chisato, Inada, Masaki

Journal:

Scientific Reports

Year:

2019

File:

PDF, 1.83 MB

2019

6

Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer’s BACE1 inhibitors

Christopher J. Monceaux, Chiho Hirata-Fukae, Polo C.-H. Lam, Maxim M. Totrov, Yasuji Matsuoka, Paul R. Carlier

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 741 KB

english, 2011

7

Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration

Kazuyuki Takata, Chiho Hirata-Fukae, Amanda G. Becker, Saori Chishiro, Audrey J. Gray, Kouhei Nishitomi, Andreas H. Franz, Gaku Sakaguchi, Akira Kato, Mark P. Mattson, Frank M. LaFerla, Paul S. Aisen,

Journal:

European Journal of Neuroscience

Year:

2007

Language:

english

File:

PDF, 764 KB

english, 2007

8

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice

Kouhei Nishitomi, Gaku Sakaguchi, Yuko Horikoshi, Audrey J. Gray, Masahiro Maeda, Chiho Hirata-Fukae, Amanda G. Becker, Motoko Hosono, Isako Sakaguchi, S. Sakura Minami, Yoshihiro Nakajima, Hui-Fang L

Journal:

Journal of Neurochemistry

Year:

2006

Language:

english

File:

PDF, 389 KB

english, 2006

9

Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage

Yasuji Matsuoka, Audrey J. Gray, Chiho Hirata-Fukae, S. Sakura Minami, Emily Graeme Waterhouse, Mark P. Mattson, Frank M. LaFerla, Illana Gozes, Paul S. Aisen

Journal:

Journal of Molecular Neuroscience

Year:

2007

Language:

english

File:

PDF, 202 KB

english, 2007

10

A novel carborane analog, BE360, with a carbon-containing polyhedral boron-cluster is a new selective estrogen receptor modulator for bone

Michiko Hirata, Masaki Inada, Chiho Matsumoto, Morichika Takita, Takumi Ogawa, Yasuyuki Endo, Chisato Miyaura

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 484 KB

english, 2009

11

Hyaluronan inhibits bone resorption by suppressing prostaglandin E synthesis in osteoblasts treated with interleukin-1

Michiko Hirata, Megumi Kobayashi, Morichika Takita, Chiho Matsumoto, Chisato Miyaura, Masaki Inada

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 403 KB

english, 2009

12

Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo

Chiho Hirata-Fukae, Elkhansa Hassan Sidahmed, Thomas P. Gooskens, Paul S. Aisen, Ilse Dewachter, Herman Devijver, Fred Van Leuven, Yasuji Matsuoka

Journal:

Neuroscience Letters

Year:

2008

Language:

english

File:

PDF, 322 KB

english, 2008

13

Role of Fezf1 and Fezf2 in the amygdala development

Tsutomu Hirata, Chiho Hirata-Fukae, Toru Kondo, Masahiko Hibi

Journal:

Neuroscience Research

Year:

2011

Language:

english

File:

PDF, 104 KB

english, 2011

14

Toll-like receptor 2 heterodimers, TLR2/6 and TLR2/1 induce prostaglandin E production by osteoblasts, osteoclast formation and inflammatory periodontitis

Chiho Matsumoto, Toshio Oda, Satoshi Yokoyama, Tsukasa Tominari, Michiko Hirata, Chisato Miyaura, Masaki Inada

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 519 KB

english, 2012

15

P4-333

Matsuoka, Yasuji, Gray, Audrey J., Li, Hui-Fang, Hirata, Chiho, Planel, Emmanuel, Duff, Karen, Mattson, Mark P., Gozes, Illana, Aisen, Paul S.

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 75 KB

english, 2006

16

P4-297

Horikoshi, Yuko, Hirata, Chiho, Gray, Audrey J., Maeda, Masahiro, Wong, Philip C., Aisen, Paul S., Kinoshita, Noriaki, Matsuoka, Yasuji

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 58 KB

english, 2006

17

The zinc finger gene Fezf2 is required for the development of excitatory neurons in the basolateral complex of the amygdala

Hirata-Fukae, Chiho, Hirata, Tsutomu

Journal:

Developmental Dynamics

Year:

2014

Language:

english

File:

PDF, 1003 KB

english, 2014

18

Heptamethoxyflavone, a citrus flavonoid, suppresses inflammatory osteoclastogenesis and alveolar bone resorption

Matsumoto, Chiho, Inoue, Hiroki, Tominari, Tsukasa, Watanabe, Kenta, Hirata, Michiko, Miyaura, Chisato, Inada, Masaki

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2015

Language:

english

File:

PDF, 275 KB

english, 2015

19

Preventive effects of low-dose aspirin on colorectal adenoma growth in patients with familial adenomatous polyposis: double-blind, randomized clinical trial

Ishikawa, Hideki, Wakabayashi, Keiji, Suzuki, Sadao, Mutoh, Michihiro, Hirata, Keiji, Nakamura, Tomiyo, Takeyama, Ikuko, Kawano, Atsuko, Gondo, Nobuhisa, Abe, Takashi, Tokudome, Shinkan, Goto, Chiho,

Journal:

Cancer Medicine

Year:

2013

Language:

english

File:

PDF, 511 KB

english, 2013

20

The Protective Effects of β-Cryptoxanthin on Inflammatory Bone Resorption in a Mouse Experimental Model of Periodontitis

MATSUMOTO, Chiho, ASHIDA, Noriyuki, YOKOYAMA, Satoshi, TOMINARI, Tsukasa, HIRATA, Michiko, OGAWA, Kazunori, SUGIURA, Minoru, YANO, Masamichi, INADA, Masaki, MIYAURA, Chisato

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2013

Language:

english

File:

PDF, 137 KB

english, 2013

21

Systematic Localization Study on Novel Proteins Encoded by Meiotically Up-Regulated ORFs in Fission Yeast

IKEBE, Chiho, KONISHI, Manabu, HIRATA, Dai, MATSUSAKA, Takahiro, TODA, Takashi

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2011

Language:

english

File:

PDF, 311 KB

english, 2011

22

Capsaicin, a TRPV1 Ligand, Suppresses Bone Resorption by Inhibiting the Prostaglandin E Production of Osteoblasts, and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide

Kobayashi, Megumi, Watanabe, Kenta, Yokoyama, Satoshi, Matsumoto, Chiho, Hirata, Michiko, Tominari, Tsukasa, Inada, Masaki, Miyaura, Chisato

Journal:

ISRN Pharmacology

Year:

2012

Language:

english

File:

PDF, 622 KB

english, 2012

23

Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice

Tominari, Tsukasa, Matsumoto, Chiho, Watanabe, Kenta, Hirata, Michiko, Grundler, Florian M.W., Miyaura, Chisato, Inada, Masaki

Journal:

Year:

2015

Language:

english

File:

PDF, 607 KB

english, 2015

24

Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis

Inada, Masaki, Takita, Morichika, Yokoyama, Satoshi, Watanabe, Kenta, Tominari, Tsukasa, Matsumoto, Chiho, Hirata, Michiko, Maru, Yoshiro, Maruyama, Takayuki, Sugimoto, Yukihiko, Narumiya, Shuh, Uemat

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.20 MB

english, 2015

25

Indoxyl sulfate exacerbates low bone turnover induced by parathyroidectomy in young adult rats

Hirata, Junya, Hirai, Kazuya, Asai, Hirobumi, Matsumoto, Chiho, Inada, Masaki, Miyaura, Chisato, Yamato, Hideyuki, Watanabe-Akanuma, Mie

Journal:

Year:

2015

Language:

english

File:

PDF, 838 KB

english, 2015

26

BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice

Watanabe, Kenta, Hirata, Michiko, Tominari, Tsukasa, Matsumoto, Chiho, Endo, Yasuyuki, Murphy, Gillian, Nagase, Hideaki, Inada, Masaki, Miyaura, Chisato

Journal:

Biochemical and Biophysical Research Communications

Year:

2016

Language:

english

File:

PDF, 949 KB

english, 2016

27

Abrogation of prostaglandin E-EP4 signaling in osteoblasts prevents the bone destruction induced by human prostate cancer metastases

Watanabe, Kenta, Tominari, Tsukasa, Hirata, Michiko, Matsumoto, Chiho, Maruyama, Takayuki, Murphy, Gillian, Nagase, Hideaki, Miyaura, Chisato, Inada, Masaki

Journal:

Biochemical and Biophysical Research Communications

Year:

2016

Language:

english

File:

PDF, 1.75 MB

english, 2016

28

The MET/VEGFR-targeted tyrosine kinase inhibitor attenuates FMS-dependent osteoclast differentiation and bone destruction induced by prostate cancer

Watanabe, Kenta, Hirata, Michiko, Tominari, Tsukasa, Matsumoto, Chiho, Fujita, Hidenori, Yonekura, Kazuhiko, Murphy, Gillian, Nagase, Hideaki, Miyaura, Chisato, Inada, Masaki

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 1.50 MB

english, 2016

29

Lutein, a carotenoid, suppresses osteoclastic bone resorption and stimulates bone formation in cultures

Tominari, Tsukasa, Matsumoto, Chiho, Watanabe, Kenta, Hirata, Michiko, Grundler, Florian M.W., Inada, Masaki, Miyaura, Chisato

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

30

Naringin Suppresses Osteoclast Formation and Enhances Bone Mass in Mice

Hirata, Michiko, Matsumoto, Chiho, Takita, Morichika, Miyaura, Chisato, Inada, Masaki

Journal:

JOURNAL OF HEALTH SCIENCE

Year:

2009

Language:

english

File:

PDF, 2.13 MB

english, 2009

31

Role of Prostaglandin E in Receptor Activator of Nuclear Factor-κB Ligand (RANKL) Expression in Osteoblasts Induced by Cell Adhesion to Bone Marrow B-lymphocytes

Hirata, Michiko, Harada, Suguru, Matsumoto, Chiho, Takita, Morichika, Miyaura, Chisato, Inada, Masaki

Journal:

JOURNAL OF HEALTH SCIENCE

Year:

2009

Language:

english

File:

PDF, 351 KB

english, 2009

32

Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis

Tominari, Tsukasa, Hirata, Michiko, Matsumoto, Chiho, Inada, Masaki, Miyaura, Chisato

Journal:

Journal of Pharmacological Sciences

Year:

2012

Language:

english

File:

PDF, 383 KB

english, 2012

33

Cell Shape and Matrix Production of Fibroblasts Cultured on Fibroin-organized Silk Scaffold with Type-II β-turn Structured (Ala-Gly-Ala-Gly-Ser-Gly)n Sequences

Hirata, Michiko, Kobayashi, Megumi, Matsumoto, Chiho, Miyaura, Chisato, Asakura, Tetsuo, Inada, Masaki

Journal:

JOURNAL OF HEALTH SCIENCE

Year:

2010

Language:

english

File:

PDF, 6.38 MB

english, 2010

34

Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency

Harada, Suguru, Tominari, Tsukasa, Matsumoto, Chiho, Hirata, Michiko, Takita, Morichika, Inada, Masaki, Miyaura, Chisato

Journal:

Journal of Pharmacological Sciences

Year:

2011

Language:

english

File:

PDF, 314 KB

english, 2011

35

In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.

Watanabe, Tsunamasa, Hatakeyama, Hiroto, Matsuda-Yasui, Chiho, Sato, Yusuke, Sudoh, Masayuki, Takagi, Asako, Hirata, Yuichi, Ohtsuki, Takahiro, Arai, Masaaki, Inoue, Kazuaki, Harashima, Hideyoshi, Koh

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.58 MB

english, 2015

36

Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption

Watanabe, Kenta, Tominari, Tsukasa, Hirata, Michiko, Matsumoto, Chiho, Hirata, Junya, Murphy, Gillian, Nagase, Hideaki, Miyaura, Chisato, Inada, Masaki

Journal:

Year:

2017

Language:

english

File:

PDF, 396 KB

english, 2017

37

Raloxifene reduces the risk of local alveolar bone destruction in a mouse model of periodontitis combined with systemic postmenopausal osteoporosis

Ichimaru, Ryota, Tominari, Tsukasa, Yoshinouchi, Shosei, Matsumoto, Chiho, Watanabe, Kenta, Hirata, Michiko, Numabe, Yukihiro, Murphy, Gillian, Nagase, Hideaki, Miyaura, Chisato, Inada, Masaki

Journal:

Archives of Oral Biology

Year:

2017

Language:

english

File:

PDF, 738 KB

english, 2017

38

Effects of O -methylated (−)-epigallocatechin gallate (EGCG) on LPS-induced osteoclastogenesis, bone resorption, and alveolar bone loss in mice

Tominari, Tsukasa, Ichimaru, Ryota, Yoshinouchi, Shosei, Matsumoto, Chiho, Watanabe, Kenta, Hirata, Michiko, Grundler, Florian M.W., Inada, Masaki, Miyaura, Chisato

Journal:

Year:

2017

Language:

english

File:

PDF, 855 KB

english, 2017

39

Lutein Enhances Bone Mass by Stimulating Bone Formation and Suppressing Bone Resorption in Growing Mice

Takeda, Hiroshi, Tominari, Tsukasa, Hirata, Michiko, Watanabe, Kenta, Matsumoto, Chiho, Grundler, Florian M. W., Inada, Masaki, Miyaura, Chisato

Year:

2017

Language:

english

File:

PDF, 3.31 MB

english, 2017

40

A Humanin Derivative Reduces Amyloid Beta Accumulation and Ameliorates Memory Deficit in Triple Transgenic Mice

Niikura, Takako, Sidahmed, Elkhansa, Hirata-Fukae, Chiho, Aisen, Paul S., Matsuoka, Yasuji, Ikezu, Tsuneya

Journal:

Year:

2011

Language:

english

File:

PDF, 2.99 MB

english, 2011

41

Effects of Polymethoxyflavonoids on Bone Loss Induced by Estrogen Deficiency and by LPS-Dependent Inflammation in Mice

Matsumoto, Shigeru, Tominari, Tsukasa, Matsumoto, Chiho, Yoshinouchi, Shosei, Ichimaru, Ryota, Watanabe, Kenta, Hirata, Michiko, Grundler, Florian, Miyaura, Chisato, Inada, Masaki

Journal:

Pharmaceuticals

Year:

2018

Language:

english

File:

PDF, 2.08 MB

english, 2018

42

Low Molecular-Weight Curdlan, (1→3)-β-Glucan Suppresses TLR2-Induced RANKL-Dependent Bone Resorption

Aizawa, Maki, Watanabe, Kenta, Tominari, Tsukasa, Matsumoto, Chiho, Hirata, Michiko, Grundler, Florian M. W., Inada, Masaki, Miyaura, Chisato

Journal:

Biological & Pharmaceutical Bulletin

Year:

2018

Language:

english

File:

PDF, 405 KB

english, 2018

43

A case of mediastinal diffuse large cell lymphoma.

YASUDA, Daisei, YAMAGAMI, Chiaki, ISHIGAMI, Masuo, HIRATA, Akihiro, OHOBAYASHI, Chiho, ITO, Hiroshi

Journal:

The Journal of the Japanese Society of Clinical Cytology

Year:

1993

File:

PDF, 11.11 MB

1993

44

Beta-Cryptoxanthin Inhibits Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption via the Suppression of Inhibitor of NF-κB Kinase Activity

Hirata, Narumi, Ichimaru, Ryota, Tominari, Tsukasa, Matsumoto, Chiho, Watanabe, Kenta, Taniguchi, Keita, Hirata, Michiko, Ma, Sihui, Suzuki, Katsuhiko, Grundler, Florian, Miyaura, Chisato, Inada, Masa

Journal:

Year:

2019

Language:

english

File:

PDF, 2.20 MB

english, 2019

45

Anti-obesity Effects of Eucommia ulmoides Leaves

Ando, Chiho, Kobayashi, Takeo, Tsukamoto, Shinya, Hirata, Tetsuya, Yamaguchi, Yasuyo, Ueda, Taro

Journal:

International Symposium on Eucommia ulmoides

Year:

2007

File:

PDF, 1.68 MB

2007

46

[IEEE 2019 Portland International Conference on Management of Engineering and Technology (PICMET) - Portland, OR, USA (2019.8.25-2019.8.29)] 2019 Portland International Conference on Management of Engineering and Technology (PICMET) - A Hierarchical Technology Element Decomposition for Co-Design Works

Minato, Nobuaki, Shimoida, Chiho, Hirata, Kenji, Fujishima, Nobuyuki, Kamiya, Takeshi, Takeda, Takashi, Yamagata, Kenji

Year:

2019

File:

PDF, 209 KB

2019